Nuclear receptor-interacting protein 1 (NRIP1) is a 1158-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48552.
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The mean pLDDT of this model is 45.9 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 77% |
What pLDDT means and how to read it
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549)
Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2,…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9KNG | X-ray | 1.5 Å | C=376-390 |
| 9KND | X-ray | 1.52 Å | B=376-390 |
| 9KNF | X-ray | 1.62 Å | C=376-390 |
| 5NTW | X-ray | 1.64 Å | P/Q/R/S=493-512 |
| 6G07 | X-ray | 1.66 Å | P/Q/R/S=493-512 |
| 6FZU | X-ray | 1.8 Å | P/Q=493-512 |
| 9KNE | X-ray | 1.8 Å | B=376-390 |
| 5NU1 | X-ray | 1.85 Å | P/Q=493-512 |
| 4S15 | X-ray | 1.9 Å | C/D=499-510 |
| 5NTN | X-ray | 1.9 Å | P/Q/R/S=493-512 |
| 6G05 | X-ray | 1.9 Å | P/Q=493-512 |
| 9KNC | X-ray | 1.9 Å | C=376-390 |
| 2GPO | X-ray | 1.95 Å | C=366-390 |
| 5NTI | X-ray | 2.4 Å | P/Q/R/S=493-512 |
| 2GPP | X-ray | 2.6 Å | C/D=366-390 |
| 9CWN | X-ray | 2.7 Å | B=121-143 |
| 4S14 | X-ray | 3.54 Å | C=499-510 |
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