Nuclear autoantigenic sperm protein (NASP) is a 788-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49321.
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The mean pLDDT of this model is 57.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 61% |
What pLDDT means and how to read it
Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA
Binds to linker H1 histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (PubMed:27618665, PubMed:8724350). Interacts with histone H3.3 (PubMed:33857403). Interacts with histones H3 and H4; NASP is a histone chaperone that stabilizes and maintains a soluble pool of histone H3-H4 dimers (PubMed:22195965). Interacts with ASF1A and ASF1B; the interaction is probably indirect and…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7V1M | X-ray | 2.83 Å | G/H=499-662 |
| 7V1L | X-ray | 2.85 Å | B=499-679 |
| 7V6P | X-ray | 2.9 Å | A=454-659 |
| 7V6Q | X-ray | 3.0 Å | D/H=454-659 |
| 7V1K | X-ray | 3.29 Å | A=499-679 |
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