C-X-C chemokine receptor type 3 (CXCR3) is a 368-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49682.
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The mean pLDDT of this model is 80.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling
Homomer. Forms heteromers with ACKR4
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8HNM | EM | 2.94 Å | R=1-361 |
| 9P0M | EM | 2.95 Å | A=1-368 |
| 8HNL | EM | 2.98 Å | R=1-361 |
| 8K2W | EM | 3.0 Å | R=1-240, R=258-361 |
| 8HNK | EM | 3.01 Å | R=1-361 |
| 8XYK | EM | 3.03 Å | R=2-368 |
| 8Y0N | EM | 3.07 Å | R=2-368 |
| 9P0L | EM | 3.1 Å | A=1-368 |
| 8XYI | EM | 3.16 Å | R=2-368 |
| 8K2X | EM | 3.2 Å | R=1-361 |
| 8XXZ | EM | 3.3 Å | R=2-368 |
| 8Y0H | EM | 3.53 Å | R=2-368 |
| 8HNN | EM | 3.6 Å | R=1-240, R=258-361 |
| 8XXY | EM | 3.68 Å | R=2-368 |
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