Host cell factor 1 (HCFC1) is a 2035-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51610.
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The mean pLDDT of this model is 46.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 73% |
What pLDDT means and how to read it
Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone…
Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide (PubMed:10920196). The majority of N- and C-terminal cleavage products remain tightly, albeit non-covalently, associated (PubMed:10920196). Interacts with POU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SUDS3), SAP30, SIN3B and FHL2…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4N39 | X-ray | 1.76 Å | B=1082-1097 |
| 4N3A | X-ray | 1.88 Å | B=1072-1097 |
| 5LWV | X-ray | 1.9 Å | A=1078-1095 |
| 6MA3 | X-ray | 2.0 Å | B=1082-1097 |
| 6MA4 | X-ray | 2.0 Å | B=1082-1097 |
| 6MA5 | X-ray | 2.0 Å | B=1082-1097 |
| 6MA2 | X-ray | 2.1 Å | B=1082-1097 |
| 4N3B | X-ray | 2.17 Å | B=1072-1097 |
| 4N3C | X-ray | 2.55 Å | B=1072-1097 |
| 4GO6 | X-ray | 2.7 Å | A/C=360-402, B/D=1806-2035 |
| 6MA1 | X-ray | 2.75 Å | B=1082-1097 |
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