Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) is a 676-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51787.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current…
Tetramer (PubMed:18165683, PubMed:19693805, PubMed:25441029, PubMed:31883792). Heterotetramer with KCNE1; targets to the membrane raft (PubMed:19693805, PubMed:20533308, PubMed:25037568). Interacts (via C-terminus) with calmodulin; forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry); the interaction is calcium-independent, constitutive, participates in the proper assembly of a…
Cell membrane, Cytoplasmic vesicle membrane, Early endosome, Membrane raft, Endoplasmic reticulum, Basolateral cell membrane, Apical cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3HFE | X-ray | 1.7 Å | A/B/C=583-611 |
| 3BJ4 | X-ray | 2.0 Å | A/B=574-622 |
| 7VVH | X-ray | 2.3 Å | A=364-533 |
| 3HFC | X-ray | 2.45 Å | A/B/C=583-611 |
| 7XNN | EM | 2.5 Å | B/C/E/G=1-676 |
| 9UJ4 | EM | 2.59 Å | A/C/E/G=1-676 |
| 7XNK | EM | 2.6 Å | A/C/E/G=1-676 |
| 7VUO | X-ray | 2.68 Å | A=364-533 |
| 9VEC | EM | 2.7 Å | A/D/G/J=75-620 |
| 4V0C | X-ray | 2.86 Å | A/B=352-539 |
| 8SIK | EM | 2.9 Å | A/C/E/G=76-620 |
| 9U7F | EM | 2.9 Å | A/D/G/J=1-676 |
| 4UMO | X-ray | 3.0 Å | A/B=352-539 |
| 6UZZ | EM | 3.1 Å | A/C/E/G=76-620 |
| 6V00 | EM | 3.1 Å | A/D/G/J=76-620 |
| 7XNL | EM | 3.1 Å | A/C/E/G=1-676 |
| 7VVD | X-ray | 3.13 Å | A/D=364-533 |
| 9UC8 | EM | 3.36 Å | A/D/G/J=1-676 |
| 12DK | EM | 3.47 Å | A/C/E/G=76-620 |
| 7XNI | EM | 3.5 Å | A/B/D/G=1-676 |
Showing 20 of 28 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.