Nuclear cap-binding protein subunit 2 (NCBP2) is a 156-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52298.
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The mean pLDDT of this model is 93.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of…
Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA (PubMed:26382858). Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Interacts with PHAX/RNUXA, EIF4G1, HNRNPF, HNRNPH1 and ALYREF/THOC4/ALY. Interacts with SRRT/ARS2 and KPNA3 (PubMed:26382858,…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1H2V | X-ray | 2.0 Å | Z=1-156 |
| 1H6K | X-ray | 2.0 Å | X/Y/Z=22-120 |
| 1N52 | X-ray | 2.11 Å | B=1-156 |
| 1H2T | X-ray | 2.15 Å | Z=1-156 |
| 3FEY | X-ray | 2.2 Å | B=1-156 |
| 1H2U | X-ray | 2.4 Å | X/Y=1-156 |
| 9HFL | EM | 2.62 Å | D=1-156 |
| 6D0Y | X-ray | 2.68 Å | A=1-156 |
| 1N54 | X-ray | 2.72 Å | B=1-156 |
| 5OOB | X-ray | 2.79 Å | B/D/G/J=1-156 |
| 5OO6 | X-ray | 2.8 Å | B/E/H/K/N/Q/T/W=1-156 |
| 8BY6 | EM | 3.19 Å | B=1-156 |
| 8SRR | EM | 3.22 Å | B=1-156 |
| 8SUY | EM | 3.38 Å | B=1-156 |
| 8PMP | EM | 3.43 Å | B=1-156 |
| 8PNT | EM | 3.46 Å | B=1-156 |
| 3FEX | X-ray | 3.55 Å | B=1-156 |
| 7ABG | EM | 7.8 Å | A1=1-156 |
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