1H6K: Nuclear Cap Binding Complex

nuclear Cap Binding Complex. Determined by X-ray diffraction at 2.0 Å resolution. Released 13 Sept 2001.

Method

X-ray diffraction

Resolution

2.0 Å

Organism

HOMO SAPIENS

Chains

6

Atoms

21,515

Mol. weight

298.33 kDa

Released

13 Sept 2001

Explore 1H6K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1H6K contains 153 α-helices and 36 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 49 helices, 6 β-strands

Molecules and chains

>1H6K_1 CBP80 (chains A, B, C)
KTSDANETEDHLESLICKVGEKSACSLESNLEGLAGVLEADLPNYKSKILRLLCTVARLL
PEKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNYNEAVYLVRFLSDLVNCHV
IAAPSMVAMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWVGKELYEKKDAEMDRIFANT
ESYLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLKKDRWQERHILRPYLAFDSI
LCEALQHNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLH
CIIKSHWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIEL
CKLQPGSLPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQ
DPESPKPKFVREVLEKCMRLSYHQRILDIVPPTFSALCPSNPTCIYKYGDESSNSLPGHS
VALCLAVAFKSKATNDEIFSILKDVPNPNQDDDDDEGFSFNPLKIEVFVQTLLHLAAKSF
SHSFSALAKFHEVFKTLAESDEGKLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAV
ANWIFSSELSRDFTRLFVWEILHSTIRKMNKHVLKIQKELEEAKEKLARQHDGVLEEQIE
RLQEKVESAQSEQKNLFLVIFQRFIMILTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQ
HHQIIQQYMVTLENLLFTAELDPHILAVFQQFCALQA

>1H6K_2 20 KDA NUCLEAR CAP BINDING PROTEIN (chains X, Y, Z)
DQHFRGDNEEQEKLLKKSCTLYVGNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKTACG
FCFVEYYSRADAENAMRYINGTRLDDRIIRTDWDAGFK

Primary citation

Crystal Structure of the Human Nuclear CAP Binding Complex. Mazza, C., Ohno, M., Segref, A. et al. Mol Cell (2001) 8:383. DOI 10.1016/S1097-2765(01)00299-4 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q09161 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 1H2V 2.0 Å, Structure of the human nuclear cap-binding-complex (CBC)
• 1H2T 2.1 Å, Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue…
• 1N52 2.11 Å, Cap Binding Complex
• 3FEY 2.2 Å, Crystal structure of the CBC-importin alpha complex.
• 1H2U 2.4 Å, Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue…
• 9HFL 2.62 Å, Cryo-EM structure of the human snRNA export complex comprising CBC-PHAX-CRM1-RanGTP and…
• 6D0Y 2.68 Å, X-ray Crystal Structure of PGC-1beta C-terminus bound to the CBP80-CBP20 Cap Binding…
• 1N54 2.72 Å, Cap Binding Complex m7GpppG free
• 5OOB 2.79 Å, Complex of human nuclear cap-binding complex with M7GTP and nelf-E C-terminal peptide
• 5OO6 2.8 Å, Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide
• 8BY6 3.19 Å, Structure of the human nuclear cap-binding complex bound to NCBP3(560-620) and…
• 8SRR 3.22 Å, Cryo-EM structure of the CBC-ALYREF complex

Browse structure collections

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