Transcription initiation factor IIA subunit 1 (GTF2A1) is a 376-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52655.
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The mean pLDDT of this model is 55.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 27% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity
TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1NVP | X-ray | 2.1 Å | B=2-58, C=303-376 |
| 5M4S | X-ray | 2.38 Å | A=2-58, A=328-376 |
| 7NVU | EM | 2.5 Å | U=1-376 |
| 7NVS | EM | 2.8 Å | U=1-376 |
| 7NVT | EM | 2.9 Å | U=1-376 |
| 8S52 | EM | 2.9 Å | U=1-376 |
| 7ZWD | EM | 3.0 Å | U=1-376 |
| 7ZX8 | EM | 3.0 Å | U=1-376 |
| 8S51 | EM | 3.1 Å | U=1-376 |
| 7ZWC | EM | 3.2 Å | U=1-376 |
| 7EGB | EM | 3.3 Å | Q=1-376 |
| 7ZX7 | EM | 3.4 Å | U=1-376 |
| 8S5N | EM | 3.4 Å | U=1-376 |
| 7ZXE | EM | 3.5 Å | U=1-376 |
| 7EG9 | EM | 3.7 Å | Q=1-376 |
| 8BZ1 | EM | 3.8 Å | U=1-376 |
| 5IYB | EM | 3.9 Å | N=1-376 |
| 5IYC | EM | 3.9 Å | N=1-376 |
| 5IYD | EM | 3.9 Å | N=1-376 |
| 7EGC | EM | 3.9 Å | Q=1-376 |
Showing 20 of 52 experimental structures (best resolution first).
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