Transcription initiation factor IIA subunit 2 (GTF2A2) is a 109-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52657.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity
TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain)…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1NVP | X-ray | 2.1 Å | D=2-109 |
| 5M4S | X-ray | 2.38 Å | A=2-103 |
| 7NVU | EM | 2.5 Å | V=1-109 |
| 7NVS | EM | 2.8 Å | V=1-109 |
| 7NVT | EM | 2.9 Å | V=1-109 |
| 8S52 | EM | 2.9 Å | V=1-109 |
| 7ZWD | EM | 3.0 Å | V=1-109 |
| 7ZX8 | EM | 3.0 Å | V=1-109 |
| 8S51 | EM | 3.1 Å | V=1-109 |
| 7ZWC | EM | 3.2 Å | V=1-109 |
| 7EGB | EM | 3.3 Å | O=1-109 |
| 7ZX7 | EM | 3.4 Å | V=1-109 |
| 8S5N | EM | 3.4 Å | V=1-109 |
| 7ZXE | EM | 3.5 Å | V=1-109 |
| 7EG9 | EM | 3.7 Å | O=1-109 |
| 8BZ1 | EM | 3.8 Å | V=1-109 |
| 5IYB | EM | 3.9 Å | O=1-109 |
| 5IYC | EM | 3.9 Å | O=1-109 |
| 5IYD | EM | 3.9 Å | O=1-109 |
| 7EGC | EM | 3.9 Å | O=1-109 |
Showing 20 of 54 experimental structures (best resolution first).
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