Oncostatin-M (Osm) is a 263-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53347.
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The mean pLDDT of this model is 74.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 28% |
What pLDDT means and how to read it
Functions as a cytokine that uses only the type II OSM receptor (heterodimers composed of OSMR and IL6ST) (PubMed:9920829). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:39532904, PubMed:8605875, PubMed:9920829). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR or OSMR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3 and…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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