Triosephosphate isomerase (TPI1) is a 249-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60174.
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The mean pLDDT of this model is 96.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 95% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis
Homodimer
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9F69 | X-ray | 1.17 Å | A=5-249 |
| 9FFC | X-ray | 1.25 Å | A=1-249 |
| 7RDE | X-ray | 1.31 Å | A/B=1-249 |
| 4UNL | X-ray | 1.5 Å | A/B=2-249 |
| 4POC | X-ray | 1.6 Å | A/B=1-249 |
| 6UPF | X-ray | 1.65 Å | A/B=2-249 |
| 2JK2 | X-ray | 1.7 Å | A/B=2-249 |
| 4ZVJ | X-ray | 1.7 Å | A/B=1-249 |
| 6UP1 | X-ray | 1.83 Å | A/B=2-249 |
| 2VOM | X-ray | 1.85 Å | A/B/C/D=2-249 |
| 4BR1 | X-ray | 1.9 Å | A/B=4-249 |
| 6UP5 | X-ray | 1.92 Å | A/B=2-249 |
| 1KLU | X-ray | 1.93 Å | C=23-37 |
| 4POD | X-ray | 1.99 Å | A/B=1-249 |
| 4UNK | X-ray | 2.0 Å | A/B=2-249 |
| 6UP8 | X-ray | 2.0 Å | A/B=2-249 |
| 7T0Q | X-ray | 2.0 Å | A/B=2-249 |
| 7UXB | X-ray | 2.0 Å | A/B=1-249 |
| 6D43 | X-ray | 2.04 Å | A/B=4-249 |
| 7UXV | X-ray | 2.15 Å | A/B=1-249 |
Showing 20 of 29 experimental structures (best resolution first).
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