Protein transport protein Sec61 subunit beta (SEC61B) is a 96-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60468.
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The mean pLDDT of this model is 57.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 33% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522).…
The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:36697828). The SEC61 channel associates with the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). Interacts with TRAM1 (PubMed:19121997)
Endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DNZ | EM | 2.57 Å | C=1-96 |
| 8DNY | EM | 2.85 Å | C=1-96 |
| 8DO0 | EM | 2.86 Å | C=1-96 |
| 8DO2 | EM | 2.95 Å | C=1-96 |
| 8DNX | EM | 2.98 Å | C=1-96 |
| 8DO1 | EM | 3.01 Å | C=1-96 |
| 8DNV | EM | 3.03 Å | C=1-96 |
| 9D6L | EM | 3.1 Å | C=1-96 |
| 9N9J | EM | 3.2 Å | E=1-96 |
| 8DO3 | EM | 3.22 Å | C=1-96 |
| 8OJ0 | EM | 3.3 Å | 3=1-96 |
| 8OJ8 | EM | 3.3 Å | 3=1-96 |
| 8DNW | EM | 3.4 Å | C=1-96 |
| 6W6L | EM | 3.84 Å | 3=1-96 |
| 9YGY | EM | 4.1 Å | E=1-96 |
| 8B6L | EM | 7.6 Å | B=1-96 |
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