Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity… (PTEN) is a 403-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60484.
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The mean pLDDT of this model is 83.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly…
Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 and with DLG1 and MAST2 in vitro (PubMed:10646847, PubMed:10760291, PubMed:11707428). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (PubMed:10748157, PubMed:15951562). Interacts with NEDD4 (PubMed:17218260). Interacts with…
Cytoplasm, Nucleus, Nucleus, PML body, Cell projection, dendritic spine, Postsynaptic density, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8X3S | X-ray | 1.87 Å | B=29-41 |
| 4O1V | X-ray | 2.0 Å | B=354-368 |
| 1D5R | X-ray | 2.1 Å | A=7-353 |
| 7PC7 | X-ray | 2.1 Å | E/F=394-403 |
| 5BZZ | X-ray | 2.2 Å | A/B/C/D=14-351 |
| 5BUG | X-ray | 2.4 Å | A/B/C/D=14-351 |
| 5BZX | X-ray | 2.5 Å | A/B/C/D=14-351 |
| 7JUL | X-ray | 2.53 Å | A=7-353, A=378-390 |
| 7JUK | X-ray | 3.15 Å | A=7-353, A=378-390 |
| 7JVX | X-ray | 3.2 Å | A=1-403 |
| 7JTX | X-ray | 3.23 Å | A=7-395 |
| 2KYL | NMR | B=391-403 |
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