Actin, cytoplasmic 1 (ACTB) is a 375-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60712.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 95.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 93% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (By similarity). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By…
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,…
Cytoplasm, cytoskeleton, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3UB5 | X-ray | 2.2 Å | A=2-375 |
| 3U4L | X-ray | 2.4 Å | A=1-375 |
| 2BTF | X-ray | 2.55 Å | A=2-375 |
| 2OAN | X-ray | 2.61 Å | A/B/C/D=1-375 |
| 1HLU | X-ray | 2.65 Å | A=2-375 |
| 8OI6 | EM | 3.59 Å | A/B/C/D=1-375 |
| 9FJY | EM | 3.79 Å | A/B/C/D=2-375 |
| 7PDZ | EM | 3.8 Å | I/J/K/L/N/O=1-375 |
| 9FJU | EM | 3.84 Å | A/B/C/D=2-375 |
| 9FQR | EM | 5.0 Å | G6/Gz/Oi/Pj/Pl/Qp=1-375 |
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