Eukaryotic initiation factor 4A-I (EIF4A1) is a 406-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P60842.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 87.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963)
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and…
Cytoplasm, perinuclear region, Cell membrane, Cytoplasm, Stress granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5ZBZ | X-ray | 1.31 Å | A=20-238 |
| 9DTS | X-ray | 1.69 Å | A/B/C/D=21-406 |
| 9I9G | X-ray | 1.7 Å | A=239-406 |
| 9AVR | X-ray | 1.91 Å | A=1-406 |
| 5ZC9 | X-ray | 2.0 Å | A=19-406 |
| 2G9N | X-ray | 2.25 Å | A/B=20-238 |
| 7PPZ | X-ray | 2.52 Å | B=20-406 |
| 9I9F | X-ray | 2.73 Å | A/B/C=239-406 |
| 2ZU6 | X-ray | 2.8 Å | A/C/D/F=20-406 |
| 7PQ0 | X-ray | 3.0 Å | B=20-406 |
| 3EIQ | X-ray | 3.5 Å | A/D=1-406 |
| 8OZ0 | EM | 3.5 Å | 1/3=1-406 |
| 8XXN | EM | 3.6 Å | 4A=1-406 |
| 6ZMW | EM | 3.7 Å | j=1-406 |
| 8HUJ | EM | 3.76 Å | A=2-406 |
| 9BLN | EM | 3.9 Å | l=20-406 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.