Signal recognition particle subunit SRP54 (SRP54) is a 504-residue protein from Canis lupus familiaris. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61010.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076, PubMed:6938958). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR…
Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6413076, PubMed:6938958). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity)
Nucleus speckle, Cytoplasm, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OBR | EM | 2.8 Å | x=1-504 |
| 6FRK | EM | 3.7 Å | x=1-504 |
| 6R6G | EM | 3.7 Å | AB=4-434 |
| 7OBQ | EM | 3.9 Å | x=1-504 |
| 2GO5 | EM | 7.4 Å | W=326-434 |
| 2J37 | EM | 8.0 Å | W=1-504 |
| 4UE5 | EM | 9.0 Å | D=1-433 |
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