Signal recognition particle subunit SRP54 (SRP54) is a 504-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61011.
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The mean pLDDT of this model is 79.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with…
Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:12244299). Interacts with RNPS1 (PubMed:14729963). Interacts with the SRP receptor subunit SRPRA (PubMed:34020957)
Nucleus speckle, Cytoplasm, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1QB2 | X-ray | 2.1 Å | A/B=326-434 |
| 6Y2Z | X-ray | 2.15 Å | A/B=1-296 |
| 6Y32 | X-ray | 2.6 Å | A/C/E/G=1-296 |
| 6Y30 | X-ray | 2.65 Å | A/B=1-296 |
| 7QWQ | EM | 2.83 Å | x=1-504 |
| 1MFQ | X-ray | 3.1 Å | C=323-441 |
| 5L3Q | X-ray | 3.2 Å | A/C=1-436 |
| 7NFX | EM | 3.2 Å | x=1-504 |
| 6Y31 | X-ray | 4.0 Å | A/B/C/D=1-296 |
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