Somatostatin (SST) is a 116-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61278.
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The mean pLDDT of this model is 65.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 63% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7T10 | EM | 2.5 Å | P=103-116 |
| 8ZBI | EM | 2.79 Å | S=103-116 |
| 7WIC | EM | 2.8 Å | L=103-116 |
| 7XAT | EM | 2.85 Å | F=103-116 |
| 7XMS | EM | 2.9 Å | L=103-116 |
| 8ZBJ | EM | 2.94 Å | S=103-116 |
| 7XMR | EM | 3.1 Å | L=103-116 |
| 7Y27 | EM | 3.48 Å | C=105-116 |
| 7WJ5 | EM | 3.72 Å | S=103-116 |
| 2MI1 | NMR | A=103-116 |
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