7XMR: Somatostatin receptor 2

CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14. Determined by electron microscopy at 3.1 Å resolution. Released 3 Aug 2022.

Method: Electron microscopy
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 5
Atoms: 6,611
Mol. weight: 133.99 kDa
Released: 3 Aug 2022

Explore 7XMR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7XMR contains 27 α-helices and 40 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	10-32	23
β-strand	34-39	6	2
α-helix	48-52	5
β-strand	185-191	7	2
β-strand	194-200	7	2
α-helix	208-210	3
α-helix	212-215	4
β-strand	220-226	7	2
β-strand	233	1	3
α-helix	234	1
β-strand	241	1	3
α-helix	242-254	13
β-strand	264-269	6	2
α-helix	271-278	8
α-helix	296-308	13
β-strand	319-323	5	2
α-helix	328-351	24

Chain B: 2 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	38-40	3
β-strand	47-51	5	4
β-strand	58-63	6	5
β-strand	69-74	6	5
β-strand	78-83	6	5
β-strand	88-94	7	5
α-helix	95	1
β-strand	100-105	6	6
β-strand	111-116	6	6
β-strand	121-125	5	6
β-strand	134-139	6	6
β-strand	146-151	6	7
β-strand	156-161	6	7
β-strand	166-170	5	7
β-strand	176-180	5	7
β-strand	187-190	4	8
β-strand	198-203	6	8
β-strand	208-212	5	8
β-strand	221-222	2	8
β-strand	231-234	4	9
β-strand	240-244	5	9
β-strand	250-254	5	9
β-strand	262-264	3	9
β-strand	273-277	5	10
β-strand	285-289	5	10
β-strand	293-297	5	10
β-strand	304-309	6	10
β-strand	315-320	6	4
β-strand	327-331	5	4
β-strand	336-339	4	4

Chain C: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	30-43	14
α-helix	48-51	4

Chain L: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	11
β-strand	11	1	11

Chain R: 14 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	40-66	27
α-helix	67-71	5
α-helix	77-94	18
α-helix	96-104	9
α-helix	113-145	33
α-helix	150-153	4
α-helix	156-172	17
α-helix	175-179	5
β-strand	181-185	5	1
β-strand	191-195	5	1
α-helix	204-213	10
α-helix	214-218	5
α-helix	219-242	24
α-helix	247-281	35
α-helix	288-314	27
α-helix	317-322	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Somatostatin receptor type 2	R	protein	406	Homo sapiens	P30874 (AlphaFold model)
Guanine nucleotide-binding protein G(i) subunit alpha-1	A	protein	354	Homo sapiens	P63096 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	B	protein	351	Homo sapiens	P62873 (AlphaFold model)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	C	protein	71	Homo sapiens	P59768 (AlphaFold model)
Somatostatin-14	L	protein	14	Homo sapiens	P61278

Sequence of entity 1 (R), FASTA

>7XMR_1 Somatostatin receptor type 2 (chains R)
DYKDDDDGAPDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYF
VVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFG
KAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSL
LVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFI
IIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALK
GMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLN
ETTETQRTEFLEVLFQGPWSHPQFEKGGGSGGGSGGSAWSHPQFEK

Sequence of entity 2 (A), FASTA

>7XMR_2 Guanine nucleotide-binding protein G(i) subunit alpha-1 (chains A)
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKCTIVKQMKTIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVTAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF

Sequence of entity 3 (B), FASTA

>7XMR_3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (chains B)
MHHHHHHGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRR
TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG
NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALW
DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI
NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY
DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 4 (C), FASTA

>7XMR_4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (chains C)
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

Sequence of entity 5 (L), FASTA

>7XMR_5 Somatostatin-14 (chains L)
AGCKNFFWKTFTSC

Primary citation

Structural insights into ligand recognition and selectivity of somatostatin receptors. Zhao, W., Han, S., Qiu, N. et al. Cell Res (2022) 32:761-772. DOI 10.1038/s41422-022-00679-x · PubMed

Other PDB entries of the same protein (UniProt P30874 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7T10 2.5 Å, CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3
7XN9 2.6 Å, Crystal structure of SSTR2 and L-054,522 complex
7XNA 2.65 Å, Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806
7T11 2.7 Å, CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3.
7WIG 2.7 Å, Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
7WIC 2.8 Å, Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
7XAT 2.85 Å, Structure of somatostatin receptor 2 bound with SST14.
7XAV 2.87 Å, Structure of somatostatin receptor 2 bound with lanreotide.
7XAU 2.97 Å, Structure of somatostatin receptor 2 bound with octreotide.
7UL5 3.1 Å, CryoEM Structure of Inactive SSTR2 bound to Nb6
7YAC 3.24 Å, Paltusotine-bound SSTR2-Gi complex
7Y24 3.25 Å, Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex

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