Transforming growth factor beta-2 proprotein (TGFB2) is a 414-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61812.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively
Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Interacts with ASPN (PubMed:17827158). Interacts with MFAP5 (By similarity)
Secreted, extracellular space, extracellular matrix, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2TGI | X-ray | 1.8 Å | A=303-414 |
| 5TX4 | X-ray | 1.88 Å | B=303-414 |
| 6XM2 | X-ray | 1.91 Å | I/J/K/L=303-414 |
| 8DC0 | X-ray | 1.93 Å | B=303-414 |
| 1TFG | X-ray | 1.95 Å | A=303-414 |
| 6I9J | X-ray | 2.0 Å | A=303-414 |
| 8FXV | X-ray | 2.2 Å | A=21-414 |
| 4KXZ | X-ray | 2.83 Å | A/B/D/E=303-414 |
| 5TY4 | EM | 2.9 Å | B=317-413 |
| 7RCO | X-ray | 2.9 Å | A/B=303-414 |
| 8FXS | X-ray | 3.15 Å | A/B=21-414 |
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