Calmodulin (CALM) is a 149-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62149.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2O5G | X-ray | 1.08 Å | A=2-149 |
| 3GOF | X-ray | 1.45 Å | A/B=2-149 |
| 3GP2 | X-ray | 1.46 Å | A=2-148 |
| 2O60 | X-ray | 1.55 Å | A=2-149 |
| 1AHR | X-ray | 1.8 Å | A=2-149 |
| 1UP5 | X-ray | 1.9 Å | A/B=2-149 |
| 2BCX | X-ray | 2.0 Å | A=2-149 |
| 2VB6 | X-ray | 2.3 Å | B=1-149 |
| 5HIT | X-ray | 2.85 Å | A=2-148 |
| 2BKI | X-ray | 2.9 Å | B/D=1-149 |
| 6BNV | EM | 4.6 Å | O/P/Q/R/S/T=4-148 |
| 2KZ2 | NMR | A=77-149 | |
| 2M3S | NMR | A=1-149 | |
| 4BYA | NMR | A=77-145 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.