14-3-3 protein epsilon (YWHAE) is a 255-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62258.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates…
Homodimer (PubMed:17085597). Heterodimerizes with YWHAZ (PubMed:16376338). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (PubMed:15696159). Interacts with ARHGEF28 (By similarity). Interacts with BEX3 (By similarity). Weakly interacts with CDKN1B (PubMed:12042314). Interacts with the 'Thr-369'…
Nucleus, Cytoplasm, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2BR9 | X-ray | 1.75 Å | A=1-233 |
| 3UAL | X-ray | 1.8 Å | A=1-232 |
| 7V9B | X-ray | 1.85 Å | A=1-232 |
| 3UBW | X-ray | 1.9 Å | A=1-234 |
| 6EIH | X-ray | 2.7 Å | A=3-232 |
| 8DGP | X-ray | 2.7 Å | A/B/C/D=1-255 |
| 8DP5 | EM | 3.1 Å | D=1-255 |
| 7C8E | X-ray | 3.16 Å | A/B=1-232 |
| 8DGN | X-ray | 3.16 Å | A=1-255 |
| 8DGM | X-ray | 3.2 Å | A=1-255 |
| 8Q1S | X-ray | 3.23 Å | A/B=1-255 |
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