Histone H4 (H4c1) is a 103-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62806.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 89.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DOW | X-ray | 1.95 Å | C/D=15-26 |
| 4AU7 | X-ray | 2.07 Å | C=18-26 |
| 5B1M | X-ray | 2.34 Å | B/F=1-103 |
| 5B1L | X-ray | 2.35 Å | B/F=1-103 |
| 2WP2 | X-ray | 2.37 Å | P/Q=2-21 |
| 8PKJ | EM | 2.5 Å | B/F=1-103 |
| 8PKI | EM | 2.58 Å | B/F=1-103 |
| 1F66 | X-ray | 2.6 Å | B/F=1-103 |
| 5XM0 | X-ray | 2.87 Å | B/F=1-103 |
| 1U35 | X-ray | 3.0 Å | B/F=1-103 |
| 7VBM | EM | 3.4 Å | B/F=1-103 |
| 5XM1 | X-ray | 3.45 Å | B/F=1-103 |
| 7DBH | EM | 3.6 Å | B/F=1-103 |
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