Ras-related protein Rab-1A (RAB1A) is a 205-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62820.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 84.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone…
May interact with YIPF5 (By similarity). Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:27334615). Interacts with GDI1; this promotes dissociation from membranes (PubMed:20176951, PubMed:23815289)
Golgi apparatus, Endoplasmic reticulum, Early endosome, Cytoplasm, cytosol, Membrane, Melanosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2WWX | X-ray | 1.5 Å | A=4-178 |
| 7EQ2 | X-ray | 1.55 Å | A/B=1-176 |
| 3SFV | X-ray | 1.73 Å | A=1-176 |
| 3TKL | X-ray | 2.18 Å | A=1-191 |
| 2FOL | X-ray | 2.63 Å | A=6-177 |
| 9MHF | EM | 2.73 Å | E=1-205 |
| 4JVS | X-ray | 2.78 Å | B=1-177 |
| 4FMC | X-ray | 2.8 Å | B/D=6-176, F=14-115 |
| 3L0I | X-ray | 2.85 Å | B/D=1-177 |
| 4FMD | X-ray | 3.05 Å | B/D=6-176, F=13-176 |
| 4FMB | X-ray | 3.2 Å | B/D/F=6-176 |
| 4IRU | X-ray | 3.2 Å | B/D/F=4-177 |
| 9MHG | EM | 3.2 Å | E=1-205 |
| 4FME | X-ray | 4.1 Å | B/E=6-176 |
| 9MHH | EM | 4.5 Å | E=1-205 |
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