Ras-related C3 botulinum toxin substrate 1 (RAC1) is a 192-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P63000.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 93.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:22843693, PubMed:23512198, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration…
Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates…
Cell membrane, Melanosome, Cytoplasm, Cell projection, lamellipodium, Cell projection, dendrite, Synapse, Nucleus, Cell projection, ruffle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9RFF | X-ray | 1.25 Å | A=1-177 |
| 9IFK | X-ray | 1.34 Å | A=1-177 |
| 1MH1 | X-ray | 1.38 Å | A=2-184 |
| 9HU8 | X-ray | 1.48 Å | A=1-177 |
| 2WKQ | X-ray | 1.6 Å | A=4-180 |
| 6X1G | X-ray | 1.6 Å | B/D=1-177 |
| 5O33 | X-ray | 1.64 Å | A=1-177 |
| 9IG1 | X-ray | 1.65 Å | A=1-177 |
| 9I1L | X-ray | 1.68 Å | A=1-177 |
| 8I5V | X-ray | 1.73 Å | B=1-177 |
| 1RYF | X-ray | 1.75 Å | A/B=1-182 |
| 1RYH | X-ray | 1.75 Å | A/B=1-182 |
| 8S1N | X-ray | 1.8 Å | A=1-177 |
| 2VRW | X-ray | 1.85 Å | A=1-184 |
| 9RFB | X-ray | 1.85 Å | A/B=1-177 |
| 2P2L | X-ray | 1.9 Å | A/B/C=1-184 |
| 2WKP | X-ray | 1.9 Å | A=4-180 |
| 5QQJ | X-ray | 1.9 Å | A=1-177 |
| 5QQD | X-ray | 1.91 Å | A=1-177 |
| 4YON | X-ray | 1.95 Å | B=1-177 |
Showing 20 of 76 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.