1RYF: PDB entry 1RYF

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase. Determined by X-ray diffraction at 1.75 Å resolution. Released 27 Jan 2004.

Method: X-ray diffraction
Resolution: 1.75 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,917
Mol. weight: 45.67 kDa
Ligands: GDP, MG
Released: 27 Jan 2004

Explore 1RYF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1RYF contains 18 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	2A-10	11	1
α-helix	16-25	10
β-strand	39-46	8	1
β-strand	49-57	9	1
β-strand	96-102	7	1
α-helix	106-111	6
α-helix	112-116	5
α-helix	117-123	7
β-strand	129-134	6	1
α-helix	136-139	4
α-helix	142-149	8
α-helix	155-157	3
α-helix	158-168	11
β-strand	172-175	4	1
α-helix	184-196	13

Chain B: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	2A-10	11	1
α-helix	16-25	10
β-strand	39-46	8	1
β-strand	49-57	9	1
β-strand	96-102	7	1
α-helix	106-111	6
α-helix	112-116	5
α-helix	117-123	7
β-strand	129-134	6	1
α-helix	136-139	4
α-helix	142-150	9
α-helix	155-157	3
α-helix	158-168	11
β-strand	172-175	4	1
α-helix	184-196	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ras-related C3 botulinum toxin substrate 1 isoform Rac1b	A, B	protein	203	Homo sapiens	P63000 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1RYF_1 ras-related C3 botulinum toxin substrate 1 isoform Rac1b (chains A, B)
GSMQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDT
AGQEDYDRLRPLSYPQTVGETYGKDITSRGKDKPIADVFLICFSLVSPASFENVRAKWYP
EVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSA
LTQRGLKTVFDEAIRAVLCPPPV

Ligands and cofactors

ID	Name	Formula	Copies
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	2
MG	Magnesium ion	Mg	2

Primary citation

Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase. Fiegen, D., Haeusler, L.C., Blumenstein, L. et al. J Biol Chem (2004) 279:4743-4749. DOI 10.1074/jbc.M310281200 · PubMed

Other PDB entries of the same protein (UniProt P63000 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9RFF 1.25 Å, Crystal Structure of Human Rac1 Fused with the Scaffold Protein POSH (residues 319-371)
9IFK 1.34 Å, Crystal structure of Kalirin/Rac1 in complex with DK-2
1MH1 1.38 Å, Small G-protein
9HU8 1.48 Å, Crystal structure of Kalirin/Rac1 in complex with MC-278.
2WKQ 1.6 Å, Structure of a photoactivatable Rac1 containing the Lov2 C450A Mutant
6X1G 1.6 Å, Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in…
5O33 1.64 Å, A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1
9IG1 1.65 Å, Crystal structure of Kalirin/Rac1 in complex with DK-652
9I1L 1.68 Å, Crystal structure of Kalirin/Rac1 in complex with RS-009
8I5V 1.73 Å, DOCK10 mutant L1903Y complexed with Rac1
1RYH 1.75 Å, Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
9TJY 1.77 Å, Crystal Structure of the Human Oncogenic Splice Variant Rac1b Fused with the Scaffold…

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