Tubulin alpha-1A chain (Tuba1a) is a 451-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P68369.
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The mean pLDDT of this model is 91.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity)
Heterodimer of alpha- and beta-tubulin (By similarity). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM (By similarity). Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity…
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, flagellum axoneme
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JZD | X-ray | 2.48 Å | C=437-451 |
| 9PND | EM | 3.19 Å | A/C=1-451 |
| 9XRL | EM | 3.74 Å | AF/AO/u=1-439 |
| 8IXA | EM | 4.2 Å | A/B/C/D/E/F/G/H/I=1-451 |
| 8IXB | EM | 4.2 Å | A/E/F/H=1-451 |
| 9SFP | EM | 4.2 Å | a=1-438 |
| 8TO0 | EM | 7.7 Å | A5/A7/A9/AM/AO/AQ/AS/AU/AW/AY/Aj/Al/An/Ap/Ar/At/Av/B0/B2/B4/B8/BA/BC/BE/BO/BQ/BS/BU/BW/BY=1-451 |
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