P68871: Hemoglobin subunit beta

Hemoglobin subunit beta (HBB) is a 147-residue protein from Homo sapiens. UniProt accession: P68871.

Function

Involved in oxygen transport from the lung to the various peripheral tissues

Disease associations

Heinz body anemias (HEIBAN); Beta-thalassemia (B-THAL); Sickle cell disease (SKCA)

Subunit structure

Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia

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Source: AlphaFold · UniProt P68871