1IRD: Human Carbonmonoxy-Haemoglobin

Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution. Determined by X-ray diffraction at 1.25 Å resolution. Released 17 Oct 2001.

Method: X-ray diffraction
Resolution: 1.25 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,607
Mol. weight: 32.33 kDa
Ligands: CMO, HEM
Released: 17 Oct 2001

Explore 1IRD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IRD contains 23 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	4-15	12
α-helix	18-20	3
α-helix	21-35	15
α-helix	37-42	6
α-helix	53-71	19
α-helix	73-75	3
α-helix	76-79	4
α-helix	81-85	5
α-helix	86-90	5
α-helix	96-112	17
α-helix	119-136	18

Chain B: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	205-215	11
α-helix	223-234	12
α-helix	236-241	6
α-helix	243-245	3
α-helix	251-256	6
α-helix	258-276	19
α-helix	281-289	9
α-helix	290-295	6
α-helix	301-318	18
α-helix	319-321	3
α-helix	324-341	18
α-helix	343-345	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Hemoglobin alpha chain	A	protein	141	Homo sapiens	P69905 (AlphaFold model)
Hemoglobin beta chain	B	protein	146	Homo sapiens	P68871 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1IRD_1 Hemoglobin alpha chain (chains A)
VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGK
KVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA
VHASLDKFLASVSTVLTSKYR

Sequence of entity 2 (B), FASTA

>1IRD_2 Hemoglobin beta chain (chains B)
VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKV
KAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGK
EFTPPVQAAYQKVVAGVANALAHKYH

Ligands and cofactors

ID	Name	Formula	Copies
CMO	Carbon monoxide	C O	2
HEM	Protoporphyrin IX containing FE	C34 H32 Fe N4 O4	2

Primary citation

Carbonmonoxy-Haemoglobin at 1.25 A Resolution. Park, S.-Y., Tame, J.R.H. To be published.

Other PDB entries of the same protein (UniProt P69905 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2W72 1.07 Å, Deoxygenated structure of a distal site hemoglobin mutant plus xe
2DN1 1.25 Å, 1.25A resolution crystal structure of human hemoglobin in the oxy form
2DN2 1.25 Å, 1.25A resolution crystal structure of human hemoglobin in the deoxy form
2DN3 1.25 Å, 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form
7DY4 1.3 Å, High resolution crystal structure of hemoglobin M Boston.
6KA9 1.4 Å, Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95…
6KAO 1.4 Å, Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Dark
6LCW 1.4 Å, Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K:…
6LCX 1.4 Å, Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K:…
7DY3 1.4 Å, High resolution crystal structure of hemoglobin M Iwate.
3S66 1.4 Å, Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R…
1J40 1.45 Å, Direct observation of photolysis-induced tertiary structural changes in human…

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