PTS system glucose-specific EIIA component (crr) is a 169-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P69783.
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The mean pLDDT of this model is 92.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed:17158705, PubMed:3129430). The enzyme II complex composed of PtsG and Crr is involved in glucose transport (PubMed:2657735). The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc, however, may be an activator for adenylate cyclase. It is an important regulatory protein for cell metabolism (PubMed:789369)
Heterodimer with glycerol kinase (glpk)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1F3Z | X-ray | 1.98 Å | A=9-169 |
| 1F3G | X-ray | 2.1 Å | A=9-169 |
| 2F3G | X-ray | 2.13 Å | A/B=2-169 |
| 1GLA | X-ray | 2.6 Å | F=2-169 |
| 1GLB | X-ray | 2.6 Å | F=2-169 |
| 1GLC | X-ray | 2.65 Å | F=2-169 |
| 1GLD | X-ray | 2.93 Å | F=2-169 |
| 1GLE | X-ray | 2.94 Å | F=2-169 |
| 4JBW | X-ray | 3.91 Å | M/N/O/P=1-169 |
| 1GGR | NMR | A=2-169 | |
| 1O2F | NMR | A=2-169 | |
| 2MP0 | NMR | B=2-169 |
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