NAD-dependent protein deacylase (cobB) is a 279-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P75960.
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The mean pLDDT of this model is 90.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase (acs) by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes
Forms a 1:1 complex with acetyl-CoA synthetase (Acs)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RXK | X-ray | 1.35 Å | A=40-279 |
| 6RXJ | X-ray | 1.6 Å | A/B=40-254 |
| 6RXS | X-ray | 1.6 Å | A=40-279 |
| 6RXQ | X-ray | 1.7 Å | A/B/C/D=40-279 |
| 6RXR | X-ray | 1.7 Å | A/B/C/D=40-279 |
| 6RXP | X-ray | 1.8 Å | A/B=40-279 |
| 6RXM | X-ray | 1.92 Å | A/B/C/D/E/F=40-279 |
| 6RXO | X-ray | 1.95 Å | A/B=40-279 |
| 1S5P | X-ray | 1.96 Å | A=40-274 |
| 6RXL | X-ray | 2.3 Å | A=40-279 |
| 8ZSF | EM | 3.24 Å | A/B/C/D/E/F/G/H/I/J/K/L=38-254 |
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