mRNA export factor RAE1 (RAE1) is a 368-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P78406.
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The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Acts as a mRNA export factor involved in nucleocytoplasmic transport (PubMed:20498086, PubMed:33849972). Plays a role in mitotic bipolar spindle formation (PubMed:17172455). May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly (PubMed:17172455)
Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (PubMed:17172455). Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847). Interacts with USP11 (PubMed:29293652)
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, spindle pole, Nucleus envelope
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MMY | X-ray | 1.65 Å | A/C/E/G=1-368 |
| 7F90 | X-ray | 2.39 Å | A/C=1-368 |
| 7VPG | X-ray | 2.49 Å | A/C/E/G=1-368 |
| 7VPH | X-ray | 2.8 Å | A/C/E/G=1-368 |
| 7F60 | X-ray | 2.85 Å | A/B=1-368 |
| 4OWR | X-ray | 3.15 Å | A=31-368 |
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