Alpha-amanitin proprotein is a 23-residue protein from Amanita phalloides. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P85421.
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The mean pLDDT of this model is 66.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 52% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:363352, PubMed:4865716, PubMed:7642577, PubMed:8702941)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8WAV | EM | 2.72 Å | N=1-8 |
| 8WAX | EM | 2.75 Å | N=1-8 |
| 8WAZ | EM | 2.76 Å | N=1-8 |
| 8WAU | EM | 2.78 Å | N=1-8 |
| 1K83 | X-ray | 2.8 Å | M=1-8 |
| 3CQZ | X-ray | 2.8 Å | M=1-8 |
| 8WAT | EM | 2.82 Å | N=1-8 |
| 8WAY | EM | 2.85 Å | N=1-8 |
| 8WB0 | EM | 2.94 Å | N=1-8 |
| 8WAW | EM | 3.02 Å | N=1-8 |
| 2VUM | X-ray | 3.4 Å | M=1-6 |
| 6EXV | EM | 3.6 Å | M=1-8 |
| 8WAK | EM | 5.47 Å | N=1-8 |
| 8WAP | EM | 5.85 Å | N=1-8 |
| 8WAN | EM | 6.07 Å | N=1-8 |
| 8WAS | EM | 6.13 Å | N=1-8 |
| 8WAQ | EM | 6.29 Å | N=1-8 |
| 8WAO | EM | 6.4 Å | N=1-8 |
| 8WAR | EM | 7.2 Å | N=1-8 |
| 8WAL | EM | 8.52 Å | N=1-8 |
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