Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1) is a 331-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P97287.
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The mean pLDDT of this model is 63.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 46% |
What pLDDT means and how to read it
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity
Interacts with HIF3A isoform 2 (via C-terminus domain) (PubMed:21546903). Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1. Interacts with BBC3, BMF and PMAIP1 (PubMed:15550399, PubMed:18589438). Interacts with BOP. Interacts with BCL2L11; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:15550399, PubMed:16543145, PubMed:27013495). Interacts with GIMAP5 and…
Membrane, Cytoplasm, Mitochondrion, Nucleus, nucleoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2NL9 | X-ray | 1.55 Å | A=154-221 |
| 4BPJ | X-ray | 1.6 Å | A=152-221 |
| 5VX2 | X-ray | 1.85 Å | A/C=152-221 |
| 4BPI | X-ray | 1.98 Å | A=152-221 |
| 4G35 | X-ray | 2.0 Å | A=152-308 |
| 3D7V | X-ray | 2.03 Å | A=154-221 |
| 5KU9 | X-ray | 2.2 Å | A/B=148-221 |
| 5MES | X-ray | 2.24 Å | A=153-221 |
| 3IO9 | X-ray | 2.4 Å | A=152-221 |
| 6DM8 | X-ray | 2.7 Å | A/B/C/D/E/F/G/H=154-302 |
| 2NLA | X-ray | 2.8 Å | A=154-221 |
| 5MEV | X-ray | 2.94 Å | A=154-221 |
| 1WSX | NMR | A=152-308 | |
| 2JM6 | NMR | B=152-308 | |
| 2ROC | NMR | A=152-308 | |
| 2ROD | NMR | A=152-308 |
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