General transcription and DNA repair factor IIH helicase/translocase subunit… (SSL2) is a 843-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00578.
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The mean pLDDT of this model is 71.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 46% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
ATP-dependent DNA translocase (PubMed:25775526). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II (PubMed:14500720, PubMed:7693549, PubMed:7813015, PubMed:7961739, PubMed:8202161, PubMed:8269516, PubMed:8631896). May have 3'-5' helicase activity alone, the TFIIH core however has no 3'-5' helicase activity (PubMed:25775526). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:7693549, PubMed:7813015, PubMed:8202161, PubMed:8269516, PubMed:8631896). In NER, TFIIH acts by opening DNA around the lesion to allow the…
Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER (PubMed:7813015). The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:25775526, PubMed:7813015, PubMed:7961739). An additional…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7O4J | EM | 2.9 Å | 7=1-843 |
| 7ML0 | EM | 3.0 Å | 7=1-843 |
| 8CEN | EM | 3.0 Å | 7=1-843 |
| 7ML4 | EM | 3.1 Å | 7=1-843 |
| 7ZS9 | EM | 3.1 Å | 7=1-843 |
| 7O4I | EM | 3.2 Å | 7=1-843 |
| 7O75 | EM | 3.2 Å | 7=1-843 |
| 7ML2 | EM | 3.4 Å | 7=1-843 |
| 7O4L | EM | 3.4 Å | 7=1-843 |
| 7O72 | EM | 3.4 Å | 7=1-843 |
| 7O73 | EM | 3.4 Å | 7=1-843 |
| 7O4K | EM | 3.6 Å | 7=1-843 |
| 8CEO | EM | 3.6 Å | 7=1-843 |
| 8UMI | EM | 3.7 Å | 7=1-843 |
| 8UOT | EM | 3.7 Å | 7=1-843 |
| 8UOQ | EM | 3.8 Å | 7=1-843 |
| 7K01 | EM | 3.9 Å | 7=1-843 |
| 7ML1 | EM | 4.0 Å | 7=1-843 |
| 7ZSA | EM | 4.0 Å | 7=1-843 |
| 8UMH | EM | 4.1 Å | 7=1-843 |
Showing 20 of 29 experimental structures (best resolution first).
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