Large neutral amino acids transporter small subunit 1 (SLC7A5) is a 507-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01650.
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The mean pLDDT of this model is 85.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Forms a heterodimer with SLC3A2 that functions as a sodium-independent transporter for large neutral amino acids (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10574970, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591). Functions as an obligatory amino acid antiporter, mediating the exchange of amino acids and amino acid-related compounds across the plasma membrane (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:11847106, PubMed:17896864). Also mediates sodium-independent exchange of iodothyronines with neutral and aromatic L-alpha-amino acids (PubMed:11564694, PubMed:12225859). Mediates exchange of…
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:25998567, PubMed:30867591, PubMed:9751058). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake…
Apical cell membrane, Cell membrane, Lysosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7DSK | EM | 2.9 Å | B=2-507 |
| 7DSL | EM | 2.9 Å | B=2-507 |
| 7DSN | EM | 3.1 Å | B=2-507 |
| 8X0W | EM | 3.1 Å | B=44-507 |
| 8IDA | EM | 3.2 Å | B=2-507 |
| 6IRS | EM | 3.3 Å | B=2-507 |
| 8XPU | EM | 3.3 Å | B=2-507 |
| 6JMQ | EM | 3.31 Å | A=1-507 |
| 7DSQ | EM | 3.4 Å | B=2-507 |
| 6IRT | EM | 3.5 Å | B=2-507 |
| 8J8L | EM | 3.56 Å | B=2-507 |
| 8J8M | EM | 3.58 Å | B=2-507 |
| 8KDI | EM | 3.58 Å | B=1-507 |
| 8KDG | EM | 3.68 Å | B=1-507 |
| 8KDJ | EM | 3.73 Å | B=1-507 |
| 8KDH | EM | 3.78 Å | B=1-507 |
| 8KDD | EM | 3.83 Å | B=1-507 |
| 8KDF | EM | 3.89 Å | B=1-507 |
| 8KDN | EM | 4.12 Å | B=1-507 |
| 8KDO | EM | 4.12 Å | B=1-507 |
Showing 20 of 21 experimental structures (best resolution first).
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