Myocyte-specific enhancer factor 2B (MEF2B) is a 365-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q02080.
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The mean pLDDT of this model is 60.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 27% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription
Interacts with HDAC7 (By similarity). Heterodimer. Interacts with HDAC9
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WC2 | X-ray | 2.1 Å | A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 |
| 1N6J | X-ray | 2.2 Å | A/B=2-94 |
| 6BYY | X-ray | 2.3 Å | A/B/C/D=73-91 |
| 6C9L | X-ray | 2.3 Å | A/B/C/D/E/F=1-93 |
| 1TQE | X-ray | 2.7 Å | P/Q/R/S=1-93 |
| 6WC5 | X-ray | 2.9 Å | A/B/C/D=2-91 |
| 6BZ1 | X-ray | 2.97 Å | A/B/C/D=1-8, A/B/C/D=73-91 |
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