Angiopoietin-1 receptor (TEK) is a 1124-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q02763.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 83.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where…
Homodimer. Heterodimer with TIE1. Interacts with ANGPT1, ANGPT2 and ANGPT4 (PubMed:15284220, PubMed:32908006, PubMed:9204896). At cell-cell contacts in quiescent cells, forms a signaling complex composed of ANGPT1 plus TEK molecules from two adjoining cells. In the absence of endothelial cell-cell contacts, interaction with ANGPT1 mediates contacts with the extracellular matrix. Interacts with…
Cell membrane, Cell junction, Cell junction, focal adhesion, Cytoplasm, cytoskeleton, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3BEA | X-ray | 2.02 Å | A=917-935 |
| 6MWE | X-ray | 2.05 Å | A/B=808-1124 |
| 7E72 | X-ray | 2.09 Å | E/F=541-735 |
| 1FVR | X-ray | 2.2 Å | A/B=808-1124 |
| 2OO8 | X-ray | 2.2 Å | X=808-1124 |
| 3L8P | X-ray | 2.4 Å | A=808-1124 |
| 2P4I | X-ray | 2.5 Å | A/B=808-1124 |
| 4X3J | X-ray | 2.5 Å | A=802-1122 |
| 5UTK | X-ray | 2.5 Å | A/B=442-741 |
| 5MYB | X-ray | 2.6 Å | A/B=443-742 |
| 9LV4 | EM | 2.67 Å | B=23-452 |
| 2OSC | X-ray | 2.8 Å | A=808-1124 |
| 2GY5 | X-ray | 2.9 Å | A=23-445 |
| 5MYA | X-ray | 2.9 Å | A/B=443-742 |
| 2WQB | X-ray | 2.95 Å | A=802-1124 |
| 2GY7 | X-ray | 3.7 Å | B=23-445 |
| 4K0V | X-ray | 4.51 Å | A=23-542 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.