Elongin-C (ELC1) is a 99-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q03071.
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The mean pLDDT of this model is 83.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 50% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair (PubMed:19920177). Prevents degradation of interacting proteins like PCL6 by the proteasome (PubMed:11864988)
Heterodimer with ELA1 (PubMed:10430890, PubMed:10753924, PubMed:10998253, PubMed:11545595, PubMed:23993092). Component of a CRL3 E3 ubiquitin ligase complex consisting of the cullin CUL3, the linker protein ELC1, the substrate receptor ELA1, and the RING protein HRT1 (PubMed:19920177). Interacts with CIN5 (PubMed:10760578). Interacts with PCL6 (PubMed:10760578). Interacts with SNF4…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5ZB2 | X-ray | 2.3 Å | B=1-99 |
| 6R7I | EM | 5.9 Å | Q=1-99 |
| 6R6H | EM | 8.4 Å | Q=1-99 |
| 1HV2 | NMR | A=1-99 |
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