E3 SUMO-protein ligase SIZ1 (SIZ1) is a 904-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04195.
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The mean pLDDT of this model is 61.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 54% |
What pLDDT means and how to read it
Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance
Interacts with UBC9 and CDC3
Cytoplasm, Nucleus, Bud neck
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3I2D | X-ray | 2.6 Å | A=112-465 |
| 5JNE | X-ray | 2.85 Å | A/E=167-445 |
| 2RNN | NMR | A=1-111 |
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