Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is a 1599-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04637.
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The mean pLDDT of this model is 55.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 55% |
What pLDDT means and how to read it
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation…
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3 (PubMed:7651417, PubMed:7935836, PubMed:9372926). Interacts with eIF3 complex, mutually exclusive with EIF4A1 or EIF4A2, EIF4E and through its N-terminus with PABPC1 (PubMed:10970864, PubMed:10996799,…
Cytoplasm, Nucleus, Cytoplasm, Stress granule
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5T46 | X-ray | 1.53 Å | B/D=592-653 |
| 5EI3 | X-ray | 1.71 Å | B=609-622 |
| 4F02 | X-ray | 2.0 Å | C/F=178-203 |
| 4AZA | X-ray | 2.16 Å | B/D=609-620 |
| 1UG3 | X-ray | 2.24 Å | A/B=1233-1571 |
| 5ZK5 | X-ray | 2.25 Å | B=609-623 |
| 2W97 | X-ray | 2.29 Å | E/F=609-622 |
| 1LJ2 | X-ray | 2.38 Å | C/D=172-199 |
| 5EHC | X-ray | 2.4 Å | B=609-622 |
| 5EIR | X-ray | 2.69 Å | B=609-622 |
| 8OZ0 | EM | 3.5 Å | 2=197-1599 |
| 6ZMW | EM | 3.7 Å | g=290-1599 |
| 8J7R | EM | 3.7 Å | B=746-992 |
| 8HUJ | EM | 3.76 Å | B=746-992 |
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