Q04844: Acetylcholine receptor subunit epsilon (CHRNE)

Acetylcholine receptor subunit epsilon (CHRNE) is a 493-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q04844.

Gene: CHRNE
Organism: Homo sapiens
Length: 493 residues
Mean pLDDT: 80.7
Model: AF-Q04844-F1 v6
Model created: 1 Aug 2025
PDB structures: 13

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Model confidence (pLDDT)

The mean pLDDT of this model is 80.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	31%
70 to 90	Confident: backbone generally right	48%
50 to 70	Low: treat with caution	17%
Below 50	Very low: often disordered regions	5%

What pLDDT means and how to read it

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Subunit structure

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996)

Subcellular location

Postsynaptic cell membrane, Cell membrane

Disease associations

Myasthenic syndrome, congenital, 4A, slow-channel (CMS4A)
Myasthenic syndrome, congenital, 4B, fast-channel (CMS4B)
Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency (CMS4C)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
9DMS	EM	1.92 Å	B=1-493
9DMG	EM	2.05 Å	B=1-493
9DMH	EM	2.06 Å	B=1-493
9DMQ	EM	2.06 Å	B=1-493
9DMV	EM	2.13 Å	B=1-493
9DMT	EM	2.18 Å	B=1-493
9DMJ	EM	2.19 Å	B=1-493
9DML	EM	2.24 Å	I=1-493
9DMK	EM	2.46 Å	B=1-493
9GU1	EM	2.48 Å	E=21-493
9GU3	EM	2.64 Å	E=21-493
9GU2	EM	2.73 Å	E=21-493
9GU0	EM	2.96 Å	E=21-493

More AlphaFold highlights

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