Q07001: Acetylcholine receptor subunit delta (CHRND)

Acetylcholine receptor subunit delta (CHRND) is a 517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07001.

Gene: CHRND
Organism: Homo sapiens
Length: 517 residues
Mean pLDDT: 83.8
Model: AF-Q07001-F1 v6
Model created: 1 Aug 2025
PDB structures: 13

Explore in 3D Color by confidence AlphaFold DB UniProt

Model confidence (pLDDT)

The mean pLDDT of this model is 83.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	50%
70 to 90	Confident: backbone generally right	33%
50 to 70	Low: treat with caution	12%
Below 50	Very low: often disordered regions	6%

What pLDDT means and how to read it

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Subunit structure

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996)

Subcellular location

Postsynaptic cell membrane, Cell membrane

Disease associations

Multiple pterygium syndrome, lethal type (LMPS)
Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A)
Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B)
Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C)

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
9DMS	EM	1.92 Å	D=1-517
9DMG	EM	2.05 Å	D=1-517
9DMH	EM	2.06 Å	D=1-517
9DMQ	EM	2.06 Å	D=1-517
9DMV	EM	2.13 Å	D=1-517
9DMT	EM	2.18 Å	D=1-517
9DMJ	EM	2.19 Å	D=1-517
9DML	EM	2.24 Å	H=1-517
9DMK	EM	2.46 Å	D=1-517
9GU1	EM	2.48 Å	D=22-517
9GU3	EM	2.64 Å	D=22-517
9GU2	EM	2.73 Å	D=22-517
9GU0	EM	2.96 Å	D=22-517

More AlphaFold highlights

About this viewer

MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.