Nuclear cap-binding protein subunit 1 (NCBP1) is a 790-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q09161.
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The mean pLDDT of this model is 94.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 90% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of…
Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Found in a U snRNA export complex containing PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PHAX/RNUXA, SRRT/ARS2, EIF4G2,…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1H2V | X-ray | 2.0 Å | C=20-790 |
| 1H6K | X-ray | 2.0 Å | A/B/C=20-790 |
| 1H2T | X-ray | 2.1 Å | C=20-790 |
| 1N52 | X-ray | 2.11 Å | A=1-790 |
| 3FEY | X-ray | 2.2 Å | A=1-790 |
| 1H2U | X-ray | 2.4 Å | A/B=20-790 |
| 9HFL | EM | 2.62 Å | C=1-790 |
| 6D0Y | X-ray | 2.68 Å | C=24-790 |
| 1N54 | X-ray | 2.72 Å | A=1-790 |
| 5OOB | X-ray | 2.79 Å | A/C/F/I=20-790 |
| 5OO6 | X-ray | 2.8 Å | A/D/G/J/M/P/S/V=20-790 |
| 8BY6 | EM | 3.19 Å | A=20-790 |
| 8SRR | EM | 3.22 Å | A=1-790 |
| 8SUY | EM | 3.38 Å | A=1-790 |
| 8PMP | EM | 3.43 Å | A=20-790 |
| 8PNT | EM | 3.46 Å | A=20-790 |
| 3FEX | X-ray | 3.55 Å | A=1-790 |
| 7ABG | EM | 7.8 Å | A5=1-790 |
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