Tripartite motif-containing protein 5 (TRIM5) is a 497-residue protein from Macaca mulatta. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q0PF16.
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The mean pLDDT of this model is 85.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the…
Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with MAP3K7/TAK1, TAB2 and TAB3 (By similarity). Interacts with HSPA8/HSC70, PSMC2, PSMC4, PSMC5 and PSMD7 (PubMed:20053985, PubMed:22078707). Interacts with SQSTM1…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3UV9 | X-ray | 1.55 Å | A=292-497 |
| 5K3Q | X-ray | 1.8 Å | A/B/C/D=94-154, A/B/C/D=229-261 |
| 5EIU | X-ray | 1.91 Å | A/D=89-159, A/D=226-265 |
| 4TKP | X-ray | 2.08 Å | B=2-92 |
| 5F7T | X-ray | 2.29 Å | E/F/H/L=89-159, E/F/H/L=226-265 |
| 5W9A | X-ray | 2.74 Å | A/B=95-287 |
| 5IEA | X-ray | 3.26 Å | A/B/C/D/F/K=89-159, A/B/C/D/F/K=226-265 |
| 4B3N | X-ray | 3.3 Å | A/B=275-493 |
| 2LM3 | NMR | A=292-497 |
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