Bone marrow stromal antigen 2 (BST2) is a 180-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q10589.
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The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:18200009, PubMed:18342597, PubMed:19036818, PubMed:19879838, PubMed:20019814, PubMed:20399176, PubMed:20419159, PubMed:20940320, PubMed:21529378, PubMed:22520941, PubMed:37922253). Its target viruses…
Parallel homodimer; disulfide-linked (PubMed:37922253). May form homotetramers under reducing conditions. Isoform 1 and isoform 2 form homodimers and also heterodimers with each other. Dimerization is essential for its antiviral activity (PubMed:10329429, PubMed:19737401, PubMed:19879838, PubMed:20399176, PubMed:20880831, PubMed:20940320, PubMed:23028328, PubMed:26378163, PubMed:31199522).…
Golgi apparatus, trans-Golgi network, Cell membrane, Membrane raft, Cytoplasm, Apical cell membrane, Late endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Q9A | X-ray | 2.1 Å | C=22-31 |
| 3MQ7 | X-ray | 2.28 Å | A/B/C/D/E/F/G/H/I/J/K/L=47-161 |
| 3NWH | X-ray | 2.6 Å | A/B/C/D=47-152 |
| 2X7A | X-ray | 2.77 Å | A/B/C/D/E/F/G/H/I/J/K=87-147 |
| 3MQ9 | X-ray | 2.8 Å | A/B/C/D/E/F/G/H=66-139 |
| 3MQC | X-ray | 2.8 Å | A/B/C/D=47-161 |
| 4P6Z | X-ray | 3.0 Å | T=1-21 |
| 3MQB | X-ray | 3.2 Å | A/B/E/F=47-161 |
| 2XG7 | X-ray | 3.45 Å | A/C=51-151 |
| 6CM9 | EM | 3.73 Å | L/N/T=2-21 |
| 6DFF | EM | 3.9 Å | L/T=2-21 |
| 6D83 | EM | 4.27 Å | L/T=2-21 |
| 6D84 | EM | 6.72 Å | L/O/R/T=2-21 |
| 6CRI | EM | 6.8 Å | N/T/Y/Z/c/d=2-21 |
| 2LK9 | NMR | A=18-47 |
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