Chromatin assembly factor 1 subunit A (RLF2) is a 606-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12495.
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The mean pLDDT of this model is 68.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair (PubMed:9030687, PubMed:9030688). CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). Plays a role in the maintenance of heterochromatin (By similarity)
Component of chromatin assembly factor 1 (CAF-1), composed of MSI1/p50, CAC2/p60 and RLF2/CAC1/p90 (By similarity). Interacts with SAS2 (PubMed:11731480)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8THW | X-ray | 2.6 Å | A/B/C=222-240 |
| 5EJO | X-ray | 2.75 Å | A=519-606 |
| 8DEI | X-ray | 2.81 Å | A/B/C/D=136-225 |
| 5JBM | X-ray | 3.0 Å | A=457-606 |
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