Kinesin-like protein KIF1A (KIF1A) is a 1690-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12756.
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The mean pLDDT of this model is 70.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites
Dimeric motor; dimerization is required for ATP-driven processive motility (By similarity). Monomer in vitro (By similarity). Interacts with PPFIA1 and PPFIA4 (By similarity). Interacts with CALM1; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (PubMed:30021165). Interacts with PPFIA2 and TANC2; both interactions allow the recruitment of…
Cytoplasm, cytoskeleton, Cell projection, neuron projection, Cell projection, axon, Cytoplasm, perinuclear region, Synapse, Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4EJQ | X-ray | 1.89 Å | A/B/C/D/E/F/G/H=458-607 |
| 4EGX | X-ray | 2.51 Å | A/B/C/D=430-607 |
| 8UTS | EM | 2.7 Å | K=1-393 |
| 9YA5 | EM | 2.95 Å | K/N=1-393 |
| 8UTU | EM | 3.0 Å | K=1-393 |
| 8UTV | EM | 3.0 Å | K=1-393 |
| 8UTN | EM | 3.1 Å | K/N=1-393 |
| 8UTQ | EM | 3.1 Å | K=1-393 |
| 8UTT | EM | 3.1 Å | K/N=1-393 |
| 9YAI | EM | 3.12 Å | K/N=1-393 |
| 8UTO | EM | 3.2 Å | K/N=1-393 |
| 8UTP | EM | 3.2 Å | K/N=1-393 |
| 9YAB | EM | 3.21 Å | K=1-393 |
| 9YA7 | EM | 3.29 Å | K=1-393 |
| 8UTR | EM | 3.3 Å | K=1-393 |
| 8UTY | EM | 3.3 Å | K/N=1-393 |
| 8UTW | EM | 3.4 Å | K=1-393 |
| 4UXO | EM | 6.3 Å | C=1-361 |
| 4UXP | EM | 6.3 Å | C=1-361 |
| 4UXR | EM | 7.0 Å | C=1-361 |
Showing 20 of 21 experimental structures (best resolution first).
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