Serine/threonine-protein kinase PAK 1 (PAK1) is a 545-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13153.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 73.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 31% |
What pLDDT means and how to read it
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase…
Homodimer; homodimerization results in autoinhibition (PubMed:30290153). Active as monomer. Interacts with GIT1 (PubMed:27012601). Component of cytoplasmic complexes, which also contains PXN, ARHGEF7 and GIT1. Interacts with NISCH (By similarity). Interacts with DVL1; mediates the formation of a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Binds to the…
Cytoplasm, Cell junction, focal adhesion, Cell projection, lamellipodium, Cell membrane, Cell projection, ruffle membrane, Cell projection, invadopodium, Nucleus, nucleoplasm, Chromosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FXZ | X-ray | 1.64 Å | A=249-545 |
| 2QME | X-ray | 1.75 Å | I=74-109 |
| 9N4U | X-ray | 1.77 Å | A/B=249-545 |
| 1YHV | X-ray | 1.8 Å | A=249-545 |
| 1YHW | X-ray | 1.8 Å | A=249-545 |
| 3Q52 | X-ray | 1.8 Å | A=248-545 |
| 8X5Z | X-ray | 1.8 Å | A=249-545 |
| 9D4V | X-ray | 1.84 Å | A/B=249-545 |
| 9D4X | X-ray | 1.85 Å | A/B=250-545 |
| 9D4Y | X-ray | 1.85 Å | A/B=249-545 |
| 9N48 | X-ray | 1.85 Å | A/B=249-545 |
| 3Q4Z | X-ray | 1.89 Å | A/B=248-545 |
| 5DEW | X-ray | 1.9 Å | A/B=249-545 |
| 9D50 | X-ray | 1.9 Å | A/B=250-545 |
| 4ZJI | X-ray | 1.99 Å | A/B/C/D=249-545 |
| 2HY8 | X-ray | 2.0 Å | 1=249-545 |
| 4DAW | X-ray | 2.0 Å | A=249-545 |
| 4EQC | X-ray | 2.01 Å | A=249-545 |
| 3Q53 | X-ray | 2.09 Å | A=248-545 |
| 5DEY | X-ray | 2.1 Å | A/B=249-545 |
Showing 20 of 41 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.