Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) is a 457-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13451.
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The mean pLDDT of this model is 92.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase…
Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place (By similarity). Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (PubMed:7693698). Interacts with NR3C1 (By similarity). Interacts with Akt/AKT1 and PHLPP1;…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AOT | X-ray | 0.85 Å | A=16-140 |
| 7APW | X-ray | 0.89 Å | A=16-140 |
| 8R5K | X-ray | 0.89 Å | A=16-140 |
| 7APS | X-ray | 0.94 Å | A/B=16-140 |
| 3O5Q | X-ray | 0.96 Å | A=16-140 |
| 6TX6 | X-ray | 0.98 Å | A=16-140 |
| 8CHN | X-ray | 0.99 Å | A=16-140 |
| 3O5P | X-ray | 1.0 Å | A=16-140 |
| 4DRQ | X-ray | 1.0 Å | A=16-140 |
| 5OBK | X-ray | 1.0 Å | A=16-140 |
| 8CHP | X-ray | 1.0 Å | A=16-140 |
| 8CHQ | X-ray | 1.01 Å | A=16-140 |
| 4JFM | X-ray | 1.02 Å | A=16-140 |
| 4TX0 | X-ray | 1.03 Å | A=16-140 |
| 4JFI | X-ray | 1.05 Å | A=16-139 |
| 6TX4 | X-ray | 1.06 Å | A=16-140 |
| 4DRN | X-ray | 1.07 Å | A=16-140 |
| 4JFJ | X-ray | 1.08 Å | A=16-140 |
| 4W9Q | X-ray | 1.08 Å | A=16-140 |
| 6TX5 | X-ray | 1.08 Å | A=16-140 |
Showing 20 of 138 experimental structures (best resolution first).
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